Nicolas Thomä

Group News

Aug 17, 2019
Function from structure: the double life of a DUB
May 30, 2019
A new mechanism for accessing damaged DNA
May 11, 2019
Protein superglue! What this means for drug discovery: TED talk by Nico Thomä
Nov 5, 2018
Clues to making drugs for "undruggable" targets
Jul 18, 2018
New EMBO and HFSP fellows at FMI
All group news

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Nicolas Thomä

The molecular basis of genome maintenance

The information stored in the genome of each cell is constantly protected against endogenous and exogenous attack. Enzymatic maintenance processes are in place that repair mutations and prevent duplication or deletion events. Thus, genetic and epigenetic information is faithfully passaged to the progeny. On a biomedical level, defects in these pathways are frequently associated with cancer. Genome integrity is maintained through large multi-component nano-machines. We focus on protein complexes at the interface of DNA repair, replication and chromatin. My laboratory has set out to combine structural biology, cell biology and complex biochemical in vitro reconstitutions to address the molecular workings of these chromatin-bound complex assemblies. Our focus is on machines that detect and repair mutations in the DNA, and those that make possible the accurate passage of epigenetic information to the daughter generation.

Contact
Nicolas Thomä




TED talk by Nico Thomä
Protein superglue! What this means for drug discovery
May 11, 2019 - Basel

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Sievers QL, Petzold G, Bunker RD, Renneville A, Slabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH (2018) Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Science. 2018 Nov 2;362(6414)

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

Nature 512:49-53

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH (2014) Crystal structure of the human COP9 signalosome

Nature. 2014 Jul 16. doi: 10.1038/nature13566. [Epub ahead of print]

Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH (2014) Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIa and RMI1

Nat Struct Mol Biol. 21:261-8

Shi T, Bunker RD, Mattarocci S, Ribeyre C, Faty M, Gut H, Scrima A, Rass U, Rubin SM, Shore D, Thomä NH (2013) Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions

Cell 153:1340-53

Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH (2011) The molecular basis of CRL4(DDB2/CSA) ubiquitin ligase architecture, targeting and release of signalosome inhibition

Cell, 147, 5, 1024-1039

Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH (2011) Histone methylation by PRC2 is inhibited by active chromatin marks

Mol Cell 42:330-41.

Scrima A, Konickova R, Czyzewski B, Kawasaki Y, Jeffrey P, Groisman R, Nakatani Y, Iwai S, Pavletich N, Thomä N (2008) Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

Cell 135:1213-1223

Full list of publications
» Search with Medline

Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Undergraduates


Alumni

PhD students

Julia Reinert (2013-2018)
Weaam Ibrahim Mohamed (2012-2018)
Alessandro Potenza (2014-2015)
Eric Fischer (2010-2013)
Tianlai Shi (2008-2012)
Cian Stutz (2008-2012)
Frank Schmitges (2006-2011)

Postdoctoral fellows

Julius Rabl (2011-2018)
Michal Walczak (2015-2017)
Richard Bunker (2011-2016)
Andreas Daniel Schenk (2015-2016)
Eric Fischer (2013-2015)
Wassim Abdul Rahman (2011-2014)
Simone Cavadini (2010-2014)
Manjappa Lingaraju G (2009-2014)
Kerstin Boehm (2010-2014)
Tianlai Shi (2012-2013)
Nicolas Bocquet (2009-2013)
Andrea Scrima (2007-2011)
Markus Vogel (2007-2010)

Technical/Research associates

Richard Bunker (2017-2019)
Mahamadou Faty (2006-2018)
Alessandro Potenza (2015-2017)
Wassim Abdul Rahman (2014-2017)
Manjappa Lingaraju G (2014-2016)
Julia Toth (2015)
Jacqueline Blunschi (2009)

Undergraduates

Eric Pfeiffer (2018-2019)
Ulrike Seeburg (2014-2015)
Eric Fischer (2008-2010)
Philipp Amsler (2007-2009)
Jonathan Aiwazian (2008-2009)
Renata Konickova (2007-2008)
Cian Stutz (2007-2008)

Visiting scientists

Seth Rubin (2016)
Lauren Monovich (2012)
Mariko Yoshizawa (2010)

Education

1999
PhD, University of Cambridge and MRC Laboratory of Molecular Biology, Cambridge, England
1995
MPhil, University of Cambridge, Cambridge, England
1994
MA, University of Cambridge, Cambridge, England

Positions held

2012-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
2006-
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2001-2006
Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, New York
1999-2001
Postdoctoral Fellow, Max Planck Institute for Molecular Physiology, Dortmund, Germany

Honors

2012
VIVA Leading Scientist Award
2002-2005
Long-Term Fellowship, Human Frontiers Science Program
1999-2001
Long-Term-Fellowship, EMBO
1995-1998
PhD Scholarship, Studienstiftung des Deutschen Volkes
1994-1995
Fellowship, Deutscher Akademischer Austauschdienst (DAAD)