Filippo M. Rijli

Group News

Oct 23, 2018
ERC Synergy Grant - epigenetics of cartilage repair and regeneration
Oct 5, 2018
Congratulations to the FMI Prize winners 2018
Jul 18, 2018
New EMBO and HFSP fellows at FMI
Mar 31, 2017
Epigenetic regulation of face formation
Feb 3, 2017
Transcriptional control of sound discrimination
All group news

Resources

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Filippo M. Rijli

Transcriptional and epigenetic regulation of craniofacial and neuronal development

Our recent work focuses on the transcriptional and epigenetic mechanisms underlying craniofacial development and the sensory mapping of facial structures in the brain. To this end, we established in vivo genome-wide approaches to identify chromatin signatures underlying the molecular identities of selected subpopulations of cranial neural crest cells and neurons of the somatosensory circuits in the mouse hindbrain (brainstem). Moreover, to explore the transcriptional mechanisms of assembly of sensory connectivity maps, we study the functional role of the Hox gene family encoding homeodomain transcription factors. We also address the role of selected epigenetic regulators, including members of Polycomb repressive complexes.

The ad hoc genetic tools we use in mice include imaging of fluorescently labeled neurons and axonal tracts, trans-synaptic viral tracing of defined subpopulations, in utero electroporation, and in vivo genome-wide analysis of gene expression and chromatin organization of cell subpopulations.

Our studies may enhance understanding of the basic molecular mechanisms that establish precise connectivity between neurons and contribute to the definition of the etiology of certain developmental craniofacial syndromes.

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Filippo M. Rijli

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Kitazawa T, Rijli FM (2018) Barrelette map formation in the prenatal mouse brainstem

Curr Opin Neurobiol 53:210-219

Kitazawa T, Rijli FM (2018) Integrating into the Rhombomere Community across the Border

Dev Cell 45(5):546-548

Kitazawa T, Rijli FM (2017) Nuclear pore protein meets transcription factor in neural fate

Neuron 96:259-261

Minoux M, Holwerda S, Vitobello A, Kitazawa T, Kohler H, Stadler M, Rijli FM (2017) Gene bivalency at polycomb domains regulates cranial neural crest positional identity

Science, 355:eaal2913

Karmakar K, Narita Y, Fadok J, Loche A, Fadok J, Genoud C, Ducret S, Di Meglio T, Thierry R, Bacelo J, Lüthi A, Rijli FM (2017) Hoxa2 and Hoxb2 are required for tonotopic map precision and sound discrimination in the mouse auditory brainstem

Cell Reports, 18:185-197

Moreno-Juan V, Filipchuk A, Antón-Bolaños N, Mezzera C, Gezelius H, Andrés B, Rodriguez Malmierca L, Susín R, Schaad O, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, López-Bendito G (2017) Prenatal thalamic waves regulate cortical area size prior to sensory processing

Nature Comm, 8:14172

Bechara A, Laumonnerie C, Vilain N, Kratochwil CF, Cankovic V, Maiorano NA, Kirschmann MA, Ducret S, Rijli FM (2015) Hoxa2 selects barrelette neuron identity and connectivity in the mouse somatosensory brainstem

Cell Reports. 2015 Oct. [Epub ahead of print]

Laumonnerie C*, Bechara A*, Vilain N, Kurihara Y, Kurihara H, Rijli FM (2015) Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem.

Development. 2015 Sep. [Epub ahead of print]
* co-first authors

Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM (2013) Mouse Hoxa2 mutations provide a model for microtia and auricle duplication

Development 140:4386-97

Di Bonito M, Narita Y, Avallone B, Sequino L, Mancuso M, Andolfi G, Franzè AM, Puelles L, Rijli FM*, Studer M* (2013) Assembly of the auditory circuitry by a hox genetic network in the mouse brainstem

PLoS Genet 9:e1003249
* corresponding authors

Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AHFM, Eichmann A, Wellik D, Ducret S, Rijli FM (2013) Ezh2 orchestrates topographic tangential migration and connectivity of mouse precerebellar neurons

Science, 339:204-207

Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, Spetz JF, Selleri L, Rijli FM (2011) Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation

Dev Cell. 20:469-82

Erzurumlu RS, Murakami Y, Rijli FM (2010) Mapping the face in the somatosensory brainstem

Nat Rev Neurosci 11:252-63

Minoux M, Rijli FM (2010) Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development

Development 137(16):2605-21

Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM (2009) Rostral and caudal pharyngeal arches share a common neural crest ground pattern

Development 136:637-645

Geisen MJ, Di Meglio T, Pasqualetti M, Ducret S, Brunet JF, Chedotal A, Rijli FM (2008) Hox paralogue group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

PLoS Biol;6(6):e142

Oury F, Murakami Y, Renaud JS, Pasqualetti M, Charnay P, Ren SY, Rijli FM (2006) Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map

Science 313:1408-1413

Full list of publications
» Search with Medline

Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Visiting scientists


Alumni

PhD students

Xinyu Liu (2016)
Dominik Kraus (2011-2016)
Alberto Loche (2011-2016)
Kajari Karmakar (2009-2015)
Claudius Kratochwil (2008-2013)
Antonio Vitobello (2008-2013)
Christophe Laumonnerie (2008-2011)

Postdoctoral fellows

Nicola Maiorano (2013-2016)
Vanja Cankovic (2013-2015)
Sjoerd Holwerda (2013-2015)
Ahmad Bechara (2008-2015)
Thomas Di Meglio (2009-2012)
Yuichi Narita (2008-2011)
Liseth Parra (2009-2010)

Visiting scientists

Mar Anibal Martinez (2018)

Education

1991
PhD, University of Pisa, Italy
1985
MSc, University of Pisa, Italy

Positions held

2008-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2001-2007
Directeur de Recherche, Centre National de la Recherche Scientifique (CNRS), Paris, France
1996-2007
Group Leader, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) Strasbourg, France
1996
Chargé de Recherche at Centre National de la Recherche Scientifique (CNRS), Paris, France
1991-1996
Postdoctoral Fellow, Laboratory of Molecular Genetics of Eucaryotes (LGME), Strasbourg, France
1987
Predoctoral Fellow, Laboratory of Cell Biology, National Cancer Institute, NIH Bethesda, USA

Honors

2018
ERC Synergy Grant
2012
Titular Professor in Neurobiology, University of Basel
2008
Privatdozent, University of Basel
2007
Prix Lacassagne du Collège de France
2006-2008
Fondation pour la Recherche Medicale Award
2006-2008
Vice-Chair National Committee 3, French Cancer Research Association
2004-
Member, Faculty of 1000, Developmental Biology
2004-
Editorial Board, Development
1999
Habilitation à Diriger des Recherches (HDR), University Louis Pasteur, Strasbourg, France
1997
EMBO Short-Term Fellowship
1992-1993
EMBO Long-Term Fellowship