Georg Keller

Group News

Feb 12, 2019
Alexander Attinger and Bo Wang awarded Pfizer Research Prize 2019
Aug 23, 2018
Motor cortex needed for sensory-guided control of movement
Sep 14, 2017
Predicting what we'll see
Jun 22, 2017
Coupling of movement and vision
Jun 11, 2017
How your brain predictions interfere with what you see: TED talk by Georg Keller
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Georg Keller

Cortical computations

Our aim is to understand the computational algorithm of neocortex. Our research is based on the central hypothesis that cortical function is governed by internal models of the environment. Sensory input is compared to predictions of sensory input based on these internal models to compute prediction errors. This would mean that much of what we perceive is not the result of what our sensory organs transmit to our brains but either the result of what we expect to perceive or the result of a large deviation from these expectations.

To investigate cortical processing, we use a combination of imaging and electrophysiological techniques to record activity of individual cortical neurons during a behavioral task performed in a virtual reality environment. We use molecular techniques to target our recordings to specific cell populations in order to identify the different functional elements of the circuit. Based on these experiments and theoretical considerations we then attempt to infer the basic functional principles underlying cortical processing.

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Georg Keller



This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation

Neuron 100: issue 2, P424-435

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions

Neuron 95:1420-1432.e5

Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex

Cell 169:1291-1302.e14
*equal contribution

Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex

Elife 6. doi:10.7554/eLife.21589
* equal contributions

Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex

Neuron 92:766-772

Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex

Nat Neurosci. 19:1658-1664
* equal contributions

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

Curr Biol 26:956-964

Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment

J Vis Exp 84:e50885, doi:10.3791/50885
* equal contributions

Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse

Neuron 74:809-815

Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird

Nature 457:187-90

Full list of publications
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Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Alumni

PhD students

David Mahringer (2013-2019)
Alexander Attinger (2013-2018)
Matthias Heindorf (2017)
Pawel Zmarz (2012-2017)
Bo Wang (2012-2017)
Aris Fiser (2013-2017)

Postdoctoral fellows

Marcus Leinweber (2012-2019)
Aris Fiser (2018-2019)
Daniel Ward (2014-2015)

Undergraduates

Jan Sobczak (2014-2016)
Felix Widmer (2015)
Alexander Attinger (2013)
Ulisses Marti-Mengual (2013)

Visiting scientists

Anders Petersen (2015-2016)
Kareny Dominguez (2013)

Education

2009
PhD, Institute of Neuroinformatics, University of Zurich, ETH Zürich
2005
MSc, Swiss Federal Institute of Technology (ETH), Zürich

Positions held

2017-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2012-2017
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2009-2012
Postdoctoral Fellow, Max Planck Institute of Neurobiology

Honors

2014
Human Frontier Science Program Career Development Award
2013
Max Planck Institute of Neurobiology Young Scientist Award
2010-2013
Human Frontier Science Program Long-term Fellowship
2009-2010
Swiss National Science Foundation Fellowship for Prospective Researchers