Prisca Liberali

Group News

Apr 25, 2019
Intestinal organoid development mimics regeneration
May 26, 2018
An organoid approach in fighting disease: TED talk by Prisca Liberali
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Logic of life

Prisca Liberali

Design principles of tissue organization

Understanding the collective properties of multicellular systems and their patterns, including how such properties arise from single-cell behavior and their self-organization, is essential in order to elucidate fundamental biological processes, such as cell reprogramming and disease.

In these systems, the roles and the molecular mechanisms of cell-to-cell variability in highly regulated cellular activities, like signal transduction, membrane trafficking and cytoskeleton dynamics have been poorly characterized.

Our laboratory develops and applies experimental and theoretical frameworks for the study of cellular heterogeneity during collective cell behavior. We use high-content genetic perturbation screens with single-cell resolution combined with advanced quantitative imaging and single-cell modeling of stem cells in 2D culture and 3D self-organizing systems. One of these systems is the development of 3D intestinal organoids from single stem cells.

This systems biology approach is used to unravel the determinants of pattern formation and to achieve a comprehensive understanding of the sources of cell-to-cell variability, and how this cell-to-cell variability affects the in vivo multicellular programming of cells.

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Prisca Liberali





This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Xavier da Silveira Dos Santos A, Liberali P (2018) From single cells to tissue self-organization

FEBS J. 2018 Nov 3. doi: 10.1111/febs.14694

Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P. (2015) Trajectories of cell-cycle progression from fixed cell populations

Nat Methods. doi: 10.1038/nmeth.3545. [Epub ahead of print]

Liberali P, Snijder B, Pelkmans L (2015) Single-cell and multivariate approaches in genetic perturbation screens

Nat Rev Genet, 16:18-32

Liberali P*, Snijder B, Pelkmans L* (2014) A hierarchical map of regulatory genetic interactions in membrane trafficking

Cell, 157:1473-87
*corresponding authors

Snijder B, Liberali P, Frechin M, Stoeger T, Pelkmans L (2013) Predicting functional gene interactions with the hierarchical interaction score

Nat Methods, 10:1089-92

Liberali P, Pelkmans L (2012) Towards quantitative cell biology

Nat Cell Biol, 14:1233

Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L (2009) Population context determines cell-to-cell variability in endocytosis and virus infection

Nature, 461:520-3

Liberali P, Rämö P, Pelkmans L (2008) Protein kinases: starting a molecular systems view of endocytosis

Annu Rev Cell Dev Biol, 24:501-23

Liberali P, Kakkonen E, Turacchio G, Valente C, Spaar A, Perinetti G, Böckmann RA, Corda D, Colanzi A, Marjomaki V, Luini A (2008) The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

EMBO J, 27:970-81

Full list of publications
» Search with Medline

Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Undergraduates


Alumni

External scientific collaborators

Daniel Baeschlin (2016)

PhD students

Ilya Lukonin (2015-2019)

Postdoctoral fellows

Aline Xavier da Silveira dos Santos (2015-2019)
Andrea Boni (2016-2017)
Stefan Uhlmann (2015)

Technical/Research associates

Markus Herrmann (2017)

Undergraduates

Anna Bailach Adsuara (2018-2019)
Jacqueline Staehlin (2015-2016)

Visiting scientists

Claudia Keller (2018)
Saadia Iftikhar (2015-2017)

Education

2008
PhD, Department of Cell Biology and Oncology, Mario Negri Sud, Italy
2004
Diploma, Department of Physical Organic Chemistry, University 'La Sapienza', Rome, Italy

Positions held

2015-
Junior group leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2015-
Assistant Professor, University of Basel, Switzerland
2011-2014
Postdoctoral fellow, Institute of Molecular Life Sciences, University of Zurich, Switzerland
2008-2011
Postdoctoral fellow, Institute of Molecular Systems Biology, ETH, Zurich, Switzerland

Honors

2017
European Research Council (ERC) Starting Grant
2015
Swiss National Science Foundation, Professorship
2008-2011
FEBS Long Term Fellowship
2003-2008
Italian Association for Cancer Research (AIRC) PhD fellowship