Andreas Lüthi

Group News

Oct 22, 2019
A fundamental neuronal microcircuit for learning
Apr 23, 2019
Stressed, anxious? Ask the brain!
Sep 22, 2018
Was passiert im Gehirn bei Angst
Jan 26, 2017
Switching between freezing and flight
Nov 4, 2016
Dem Meister der Angst auf der Spur
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Andreas Lüthi

Cellular mechanisms of learning and memory

Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. We are interested in understanding the underlying mechanisms at the molecular, cellular and circuit levels. As a model system, we are using classical (Pavlovian) fear conditioning, a simple form of associative learning that is particularly suitable for study in rodents.

The inability to control or inhibit inappropriate fear responses is a hallmark of human anxiety disorders. We are investigating the cellular mechanisms underlying fear extinction, an associative learning process mediating inhibitory control of inappropriate fear behavior.

Using a multidisciplinary and integrated experimental approach in mice, we are combining in vitro and in vivo electrophysiology, imaging, molecular biology, genetics, and behavioral techniques to identify the synaptic and cellular constituents of neural circuits in the amygdala underlying the acquisition, encoding and extinction of fear memory - the microcircuitry of fear conditioning.

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Andreas Lüthi

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Jan Gründemann*, Yael Bitterman*, Tingjia Lu, Sabine Krabbe, Benjamin F. Grewe, Mark J. Schnitzer & Andreas Lüthi (2019) Amygdala Ensembles Encode Behavioral States

Science, Vol. 364, Issue 6437, eaav8736
* Co-first authors -- Publication available open access

Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Kovacevic A, Tovote P, Lüthi A (2017) A competitive inhibitory circuit for selection of active and passive fear responses

Nature 542, 96-100

Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker J, Marshall JD, Larkin MC, Jercog P, Grenier F, Li JZ, Lüthi A, Schnitzer MJ (2017) Neural ensemble dynamics underlying long-term associative memory

Nature 543, 670-675

Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schitzer MJ, Callaway EM, Lüthi A (2016) Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

Cell 167:961-972

Vogel E*, Krabbe S*, Gründemann J, Wamsteeker Cusulin JI, Lüthi A (2016) Projection-specific dynamic regulation of inhibition in amygdala micro-circuits

Neuron 91: 644-651
* Co-first author

Tovote P*, Esposito MS*, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SBE, Ramakrishnan C, Fenno L, Deisseroth K, Herry C, Arber S, Lüthi A (2016) Midbrain circuits for defensive behavior

Nature 534:206-212
* Co-first author

Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A (2015) Regulating anxiety with extrasynaptic inhibition

Nature Neurosci 18:1493-1500

Wolff SBE*, Gründemann J*, Tovote P, Krabbe S, Jacobson GA, Xu C, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A (2014) Amygdala interneuron subtypes control fear learning through disinhibition

Nature 509:453-458
*Co-first author

Senn V*, Wolff SBE*, Herry C, Grenier F, Ehrlich I, Gründemann J, Fadok JP, Müller C, Letzkus JJ, Lüthi A (2014) Long-range connectivity defines behavioral specificity of amygdala neurons

Neuron 81: 428-437
*Co-first author

Letzkus JJ*, Wolff SBE*, Meyer EMM, Tovote P, Courtin J, Herry C, Lüthi A (2011) A disinhibitory microcircuit for associative fear learning in auditory cortex

Nature 480: 331-335
*Co-first author

Ciocchi S*, Herry C*, Grenier F, Wolff SBE, Letzkus, JJ, Vlachos I, Ehrlich I, Sprengel R, Deisseroth K, Stadler M, Müller C, Lüthi A (2010) Encoding of conditioned fear in central amygdala inhibitory circuits

Nature 468: 277-282
*Co-first author

Haubensak W, Kunwar P, Cai H, Ciocchi S, Wall N, Ponnusami R, Biag J, Dong HW, Deisseroth K, Callaway EM, Fanselow MS, Lüthi A, Anderson DJ (2010) Genetic dissection of an amygdala microcircuit that gates conditioned fear

Nature 468: 270-276.

Gogolla N, Caroni P, Lüthi A, Herry C (2009) Perineuronal nets protect fear memories from erasure

Science 325:1258-1261

Fourcaudot E*, Gambino F*, Humeau Y, Casassus G, Poulain B, Lüthi A (2009) L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

Nature Neurosci 12:1093-1095
*Co-first author

Herry C, Ciocchi S, Senn V, Demmou L, Müller C, Lüthi A (2008) Switching on and off fear by distinct neuronal circuits

Nature 454:600-606

Shaban H, Humeau Y, Herry C, Casassus G, Shigemoto R, Ciocchi S, Barbieri, S, van der Putten H, Kaupmann K, Bettler B, Lüthi A (2006) Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition

Nature Neurosci 9:1028-1035

Humeau Y, Herry C, Kemp N, Shaban H, Fourcaudot E, Bissiere S, Lüthi A (2005) Dendritic spine heterogeneity determines afferent-specific hebbian plasticity in the amygdala

Neuron 45:119-131

Humeau Y, Shaban H, Bissière S, Lüthi A (2003) Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain

Nature 426:841-845

Bissière S, Humeau Y, Lüthi A (2003) Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition

Nature Neurosci 6:587-592

Full list of publications
» Search with Medline

Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Visiting scientists


Alumni

PhD students

Elisabeth Martha Maria Meyer (2010-2017)
Milica Markovic (2009-2017)
Lynda Demmou (2007-2016)
Elisabeth Vogel (2010-2015)
Paolo Botta (2009-2014)
Steffen Wolff (2008-2014)
Verena Senn (2004-2009)
Stéphane Ciocchi (2004-2009)
Ulrich Pfeiffer (2006-2008)
Elodie Fourcaudot (2003-2008)
Sunil Prabhakar (2006-2007)
Karin Loretan (2004-2006)
Hamdy Shaban (2002-2005)
Stephanie Bissiere (2000-2004)

Postdoctoral fellows

Lema Massi (2012-2018)
Jan Gruendemann (2011-2017)
Jonathan Fadok (2010-2017)
Philip Tovote (2009-2017)
Chun Xu (2009-2016)
Paolo Botta (2014-2015)
Tingjia Lu (2011-2015)
Jaclyn Cusulin (2014)
Johannes Letzkus (2007-2013)
Rogier Poorthuis (2013)
Francois Grenier (2005-2013)
Philippe Gastrein (2007-2012)
Joao Bacelo (2008-2012)
Stéphane Ciocchi (2009-2010)
Verena Senn (2009-2010)
Ingrid Ehrlich (2006-2009)
Cyril Herry (2003-2008)
Guillaume Casassus (2005-2008)
Yann Humeau (2002-2005)
Christine Gebhardt (2004-2005)

Technical/Research associates

Tingjia Lu (2015-2017)
Aleksandar Kovacevic (2015-2017)
Kristine Bylund (2013-2015)
Julia Luedke (2011-2013)
Maria Rita Meins (2008-2012)
Ronald Koenig (2003-2006)
Augustyn Bogucki (2003-2004)

Undergraduates

Julian Hinz (2017)
Dominic Trojer (2007-2009)
Stefan Kucsera (2006-2008)
Magali Klaey (2006)
Christian Mueller (2006)
Dorothea Haemmerer (2004-2005)
Karin Loretan (2003-2004)

Visiting scientists

Nikolaos Karalis (2017-2018)
Philip Tovote (2017)
Enrica Paradiso (2015-2016)
Karen Lavi (2012-2016)
Supriya Ghosh (2011)
Elisabeth Vogel (2009-2010)
Heidrun Baechli (2003-2006)

Education

1996
PhD, University of Basel, Basel
1992
MSc, University of Basel, Basel

Positions held

2005-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
2003-2004
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel; Assistant Professor, Biozentrum, University of Basel
2000-2003
Assistant Professor, Biozentrum, University of Basel, Basel
1998-2000
Postdoctoral Research Assistant, Brain Research Institute, University of Zurich
1996-1998
Postdoctoral Research Assistant, Department of Anatomy, University of Bristol, UK

Honors

2006
Pfizer Research Prize
2003
Titular Professor, University of Basel
2003
Swiss National Science Foundation, Professorship
2000
Borderline Personality Disorder Research Foundation, Junior Investigator Award
1996
Human Frontier Science Program, Long-Term Fellowship
1996
EMBO, Long-Term Fellowship
1996
European Union Fellowship